The last decade hasn’t been smooth. Brewster rattles off challenges: tariffs on equipment and consumables sourced from China, Europe, Mexico, and Canada; price hikes on vinyl and paper; labor shortages; and SBA lending issues layered on top of the whiplash of COVID, when only “necessary businesses” were allowed to stay open.
有趣的是，Infigratinib最初于2021年获批用于胆管癌，后因适应症开发策略调整而主动撤回。如今，其有望在ACH赛道迎来“第二春”。基于其疗效和口服便利性，BridgeBio在今年的JPM大会上预测，该药Infigratinib将占据ACH治疗市场50%以上的份额。
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